Search | VHL CLAP/WR-PAHO/WHO

1.

IL-6 Revisited: From Rheumatoid Arthritis to CAR T Cell Therapy and COVID-19.

Kishimoto, Tadamitsu; Kang, Sujin.

Annu Rev Immunol ; 40: 323-348, 2022 04 26.

Article in English | MEDLINE | ID: mdl-35113729

2.

Targeting Interleukin-6 Signaling in Clinic.

Kang, Sujin; Tanaka, Toshio; Narazaki, Masashi; Kishimoto, Tadamitsu.

Immunity ; 50(4): 1007-1023, 2019 04 16.

Article in English | MEDLINE | ID: mdl-30995492

3.

Gp130-HIF1α axis-induced vascular damage is prevented by the short-term inhibition of IL-6 receptor signaling.

Kang, Sujin; Onishi, Shinya; Ling, Zhenzhen; Inoue, Hitomi; Zhang, Yingying; Chang, Hao; Zhao, Hui; Wang, Tong; Okuzaki, Daisuke; Matsuura, Hiroshi; Takamatsu, Hyota; Oda, Jun; Kishimoto, Tadamitsu.

Proc Natl Acad Sci U S A ; 121(2): e2315898120, 2024 Jan 09.

Article in English | MEDLINE | ID: mdl-38165930

4.

Threonine phosphorylation of STAT1 restricts interferon signaling and promotes innate inflammatory responses.

Metwally, Hozaifa; Elbrashy, Maha M; Ozawa, Tatsuhiko; Okuyama, Kazuki; White, Jason T; Tulyeu, Janyerkye; Søndergaard, Jonas Nørskov; Wing, James Badger; Muratsu, Arisa; Matsumoto, Hisatake; Ikawa, Masahito; Kishi, Hiroyuki; Taniuchi, Ichiro; Kishimoto, Tadamitsu.

Proc Natl Acad Sci U S A ; 121(17): e2402226121, 2024 Apr 23.

Article in English | MEDLINE | ID: mdl-38621137

5.

IL-6/gp130 signaling in CD4⁺ T cells drives the pathogenesis of pulmonary hypertension.

Ishibashi, Tomohiko; Inagaki, Tadakatsu; Okazawa, Makoto; Yamagishi, Akiko; Ohta-Ogo, Keiko; Asano, Ryotaro; Masaki, Takeshi; Kotani, Yui; Ding, Xin; Chikaishi-Kirino, Tomomi; Maedera, Noriko; Shirai, Manabu; Hatakeyama, Kinta; Kubota, Yoshiaki; Kishimoto, Tadamitsu; Nakaoka, Yoshikazu.

Proc Natl Acad Sci U S A ; 121(16): e2315123121, 2024 Apr 16.

Article in English | MEDLINE | ID: mdl-38602915

6.

CD5: A New Partner for IL-6.

Masuda, Kazuya; Kishimoto, Tadamitsu.

Immunity ; 44(4): 720-2, 2016 Apr 19.

Article in English | MEDLINE | ID: mdl-27096313

7.

Aryl hydrocarbon receptor is essential for the pathogenesis of pulmonary arterial hypertension.

Masaki, Takeshi; Okazawa, Makoto; Asano, Ryotaro; Inagaki, Tadakatsu; Ishibashi, Tomohiko; Yamagishi, Akiko; Umeki-Mizushima, Saori; Nishimura, Manami; Manabe, Yusuke; Ishibashi-Ueda, Hatsue; Shirai, Manabu; Tsuchimochi, Hirotsugu; Pearson, James T; Kumanogoh, Atsushi; Sakata, Yasushi; Ogo, Takeshi; Kishimoto, Tadamitsu; Nakaoka, Yoshikazu.

Proc Natl Acad Sci U S A ; 118(11)2021 03 16.

Article in English | MEDLINE | ID: mdl-33836606

8.

Roles of RNA-binding proteins in immune diseases and cancer.

Hashimoto, Shigeru; Kishimoto, Tadamitsu.

Semin Cancer Biol ; 86(Pt 3): 310-324, 2022 11.

Article in English | MEDLINE | ID: mdl-35351611

9.

Epithelial miR-215 negatively modulates Th17-dominant inflammation by inhibiting CXCL12 production in the small intestine.

Pareek, Siddhika; Sanchenkova, Xenia; Sakaguchi, Taiki; Murakami, Mari; Okumura, Ryu; Kayama, Hisako; Kawauchi, Saya; Motooka, Daisuke; Nakamura, Shota; Okuzaki, Daisuke; Kishimoto, Tadamitsu; Takeda, Kiyoshi.

Genes Cells ; 27(4): 243-253, 2022 Apr.

Article in English | MEDLINE | ID: mdl-35075728

10.

Arid5a, an RNA-Binding Protein in Immune Regulation: RNA Stability, Inflammation, and Autoimmunity.

Nyati, Kishan Kumar; Zaman, Mohammad Mahabub-Uz; Sharma, Praveen; Kishimoto, Tadamitsu.

Trends Immunol ; 41(3): 255-268, 2020 03.

Article in English | MEDLINE | ID: mdl-32035762

11.

IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome.

Kang, Sujin; Tanaka, Toshio; Inoue, Hitomi; Ono, Chikako; Hashimoto, Shoji; Kioi, Yoshiyuki; Matsumoto, Hisatake; Matsuura, Hiroshi; Matsubara, Tsunehiro; Shimizu, Kentaro; Ogura, Hiroshi; Matsuura, Yoshiharu; Kishimoto, Tadamitsu.

Proc Natl Acad Sci U S A ; 117(36): 22351-22356, 2020 09 08.

Article in English | MEDLINE | ID: mdl-32826331

12.

IL-6: from arthritis to CAR-T-cell therapy and COVID-19.

Kishimoto, Tadamitsu.

Int Immunol ; 33(10): 515-519, 2021 09 25.

Article in English | MEDLINE | ID: mdl-33715009

13.

Feedback regulation of Arid5a and Ppar-Î³2 maintains adipose tissue homeostasis.

Chalise, Jaya Prakash; Hashimoto, Shigeru; Parajuli, Gyanu; Kang, Sujin; Singh, Shailendra Kumar; Gemechu, Yohannes; Metwally, Hozaifa; Nyati, Kishan Kumar; Dubey, Praveen Kumar; Zaman, Mohammad Mahabub-Uz; Nagahama, Yasuharu; Hamza, Hanieh; Masuda, Kazuya; Kishimoto, Tadamitsu.

Proc Natl Acad Sci U S A ; 116(30): 15128-15133, 2019 07 23.

Article in English | MEDLINE | ID: mdl-31289228

14.

Regulation of inflammatory responses by dynamic subcellular localization of RNA-binding protein Arid5a.

Higa, Mitsuru; Oka, Masahiro; Fujihara, Yoshitaka; Masuda, Kazuya; Yoneda, Yoshihiro; Kishimoto, Tadamitsu.

Proc Natl Acad Sci U S A ; 115(6): E1214-E1220, 2018 02 06.

Article in English | MEDLINE | ID: mdl-29358370

15.

Humanized cereblon mice revealed two distinct therapeutic pathways of immunomodulatory drugs.

Gemechu, Yohannes; Millrine, David; Hashimoto, Shigeru; Prakash, Jaya; Sanchenkova, Ksenia; Metwally, Hozaifa; Gyanu, Parajuli; Kang, Sujin; Kishimoto, Tadamitsu.

Proc Natl Acad Sci U S A ; 115(46): 11802-11807, 2018 11 13.

Article in English | MEDLINE | ID: mdl-30373817

16.

Arid5a stabilizes OX40 mRNA in murine CD4⁺ T cells by recognizing a stem-loop structure in its 3'UTR.

Hanieh, Hamza; Masuda, Kazuya; Metwally, Hozaifa; Chalise, Jaya P; Mohamed, Maged; Nyati, Kishan K; Standley, Daron M; Li, Songling; Higa, Mitsuru; Zaman, Mohammad M; Kishimoto, Tadamitsu.

Eur J Immunol ; 48(4): 593-604, 2018 04.

Article in English | MEDLINE | ID: mdl-29244194

17.

TLR4-induced NF-κB and MAPK signaling regulate the IL-6 mRNA stabilizing protein Arid5a.

Nyati, Kishan K; Masuda, Kazuya; Zaman, Mohammad Mahabub-Uz; Dubey, Praveen K; Millrine, David; Chalise, Jaya P; Higa, Mitsuru; Li, Songling; Standley, Daron M; Saito, Kazunobu; Hanieh, Hamza; Kishimoto, Tadamitsu.

Nucleic Acids Res ; 45(5): 2687-2703, 2017 03 17.

Article in English | MEDLINE | ID: mdl-28168301

18.

Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production.

Millrine, David; Tei, Mami; Gemechu, Yohannes; Kishimoto, Tadamitsu.

Proc Natl Acad Sci U S A ; 113(38): 10625-30, 2016 09 20.

Article in English | MEDLINE | ID: mdl-27601648

19.

Reply to Cheng et al.: COVID-19 induces lower extent of cytokines, but damages vascular endothelium by IL-6 signaling.

Kang, Sujin; Tanaka, Toshio; Inoue, Hitomi; Ono, Chikako; Hashimoto, Shoji; Kioi, Yoshiyuki; Matsumoto, Hisatake; Matsuura, Hiroshi; Matsubara, Tsunehiro; Shimizu, Kentaro; Ogura, Hiroshi; Matsuura, Yoshiharu; Kishimoto, Tadamitsu.

Proc Natl Acad Sci U S A ; 118(21)2021 05 25.

Article in English | MEDLINE | ID: mdl-33972413

20.

Arid5a exacerbates IFN-Î³-mediated septic shock by stabilizing T-bet mRNA.

Zaman, Mohammad Mahabub-Uz; Masuda, Kazuya; Nyati, Kishan Kumar; Dubey, Praveen Kumar; Ripley, Barry; Wang, Kai; Chalise, Jaya Prakash; Higa, Mitsuru; Hanieh, Hamza; Kishimoto, Tadamitsu.

Proc Natl Acad Sci U S A ; 113(41): 11543-11548, 2016 10 11.

Article in English | MEDLINE | ID: mdl-27671645

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Latin-American Center for Perinatology, Woman and Reproductive Health

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